Fig. 2
Reproduced with permission from [79]
The knockout of LRRc17 can alleviate MSCs senescence and promote osteogenic differentiation. a The knockout of LRRc17 can alleviate the senescence of MSCs and enhance the osteogenic differentiation potential in vitro. b–d Transplantation of senescent MSCs with LRRc17 knocked out in osteoporosis mouse models can reverse the functional decline of MSCs caused by aging. e Transplantation of senescent MSCs with LRRc17 knocked out in osteoporosis mouse models can reduce bone defect area.