Fig. 2

Secretomes are not as effective as cells in inducing wound closure. A Illustrative images depict the procedure of inducing full-thickness skin wounds in mice. B Representative images of wounds 21 days after the surgical procedure. The white dotted circle represents the initial size of the wounds, and the yellow lines highlight the final borders. Scale bar: 1 cm. C Violin plots presenting the percentage of animals with closed wounds on day 21. D Day of Integra silicone layer detachment. Silicone layers that did not detach by the study's endpoint (day of euthanasia) were considered day 22 for statistical purposes and are indicated by a red dotted rectangle. Each dot represents one animal evaluated. *p < 0.05 and **p < 0.01 by Student’s t test (control vs. each treated group; each cell vs. the respective secretome group)