Fig. 4

Matrix remodeling and reepithelization in cell- and secretome-treated wounds. A Representative images of graft collagen layer remodeling and B the corresponding quantification at day 21 post-wounding. Scale bar: 50 µm. C Representative images of the epidermis thickness in normal skin and scars. The black arrows indicate its thickness. Scale bar: 50 µm. D Ratio between neoepidermis and the normal epidermis thickness. The red dotted line shows the thickness value of the normal epidermis. Each data point represents the evaluation of one animal. *p < 0.05, **p < 0.01 and ***p < 0.001 by Student’s t test (control vs. treated groups; cells vs. secretomes groups)