Table 1 Differentially expressed proteins (p < 0.05) in seDSC and seASC with described roles on skin wound healing
Protein | seDSC | seASC | Function |
|---|---|---|---|
A2M | – | ++ | Anti-protease. Inhibits fibrinolysis and coagulation processes |
ABI3BP | ++ | +++ | Inhibits proliferation and induces MSC differentiation |
ANGPT1 | ++ | – | Development, maturation, vascular stability, and angiogenesis |
CCBE1 | ++ | – | Angiogenesis and lymphoangiogenesis |
CFL1 | ↑++ | ++ | Cell polarity and migration |
CHI3L1 | +++ | ↑+++ | Inflammation and tissue remodeling |
COL15A1 | ++ | ↑++ | Structural protein that stabilizes microvessels |
COL5A1 | +++ | ↑+++ | Regulates the diameter of collagen fibrils |
COMP | +++ | ↑+++ | Increased in fibrotic scars; potential role in vascular remodeling |
DDX42 | ++ | – | Involved in cell viability |
ECM2 | – | ++ | Facilitates matrix organization and cellular adhesion |
EIF3D | ++ | – | Regulates proliferation, differentiation, and apoptosis |
FERMT2 | ++ | ↑++ | Mediates focal adhesion. Participates in the connection between extracellular matrix and cytoskeleton, and modulates cellular morphology |
GREM1/2 | ↑+ | + | BMP antagonist. Stimulates viability, proliferation, and osteogenic and chondrogenic differentiation |
HSPG2 | ++ | +++ | Regulates vascular response after injury. Anti-angiogenic action |
IGFBP2 | ++ | – | Inhibits IGF-dependent cell proliferation |
IGFBP5 | – | ++ | Controls cell survival, differentiation, and apoptosis |
IL-6 | ++ | +++ | Can act as a pro- or anti-inflammatory cytokine. Immunomodulatory, angiogenic, and anti-apoptotic effects |
IQGAP2 | ++ | – | Interacts with the cytoskeleton, adhesion molecules, and signaling pathways to regulate cellular morphology and motility |
LAMA1 | – | ++ | Mediates cell adhesion, migration, and tissue organization |
MMP9 | ++ | +++ | Degrades collagen IV and V, along with other extracellular proteins |
NOV | ++ | ↑++ | Modulates proliferation, adhesion, migration, differentiation, and cell survival. Induces angiogenesis and acts as a receptor ligand for integrins. Stimulates fibroblast adhesion and chemotaxis and decreases the adherence of inflammatory monocytes. Suppresses MMP9 expression |
PARP1 | ++ | – | Modulates the expression of inflammatory genes and is involved in DNA repair, genomic stability, and apoptosis |
PCDH7 | ++ | – | Induces platelet degranulation, cell–cell recognition, and adhesion |
PLAU | ++ | ↑++ | Functions as a protease in tissue remodeling and cell migration |
PTGIS | – | ++ | Synthesizes prostaglandin I2, induces vasodilation, and inhibits platelet aggregation |
RARRES2 | – | ++ | Modulates inflammation, acts as a chemotactic agent for leukocytes, and exhibits antimicrobial effects on the skin. Induces adipogenesis and angiogenesis and regulates lipid and glucose metabolism |
SBSN | – | ++ | Controls epidermal differentiation |
SEMA7A | ++ | +++ | Regulates cell migration and immune responses. Stimulates focal adhesion and the production of inflammatory cytokines |
SERPINE1 | +++ | ↑+++ | Protease inhibitor |
SERPINE2 | ↑+++ | +++ | Protease inhibitor |
SLIT2 | ++ | ↑++ | Inhibits migration, proliferation, chemotaxis, and angiogenesis |
SPARC | +++ | ↑+++ | Cell–matrix interactions. Stimulates MMP, angiogenesis, proliferation, and migration |
TGFB1 | + | ++ | Controls cell proliferation and differentiation |
THBS2 | +++ | ↑+++ | Modulates adhesion and migration of mesenchymal cells |
TIMP1 | +++ | ↑+++ | Inhibits MMP and apoptosis and promotes proliferation |
VCAN | ++ | +++ | Regulates cell motility, proliferation, and differentiation. May participate in intercellular signaling |
VCL | ↑+++ | +++ | Enhances cell adhesion |