Fig. 3

Human donor photoreceptors do not transfer cargo to the mouse ONL 21 days post-transplantation. A Representative image of week 10 CRX-GFP⁺ photoreceptors transplanted into Nrl^−/− recipients, stained for GFP (green), human mitochondria (red), and nuclei (blue). B Representative image of week 14 CRX-GFP⁺ photoreceptors transplanted into NSG recipients, stained for GFP (green), human recoverin (cyan), and human mitochondria (red). The dashed lines denote the host ONL. Scale bar = 20 μm. Quantification of donor cell number in the SRS of C Nrl^−/− and D NSG recipients 21 days post-transplantation, mean ± SEM (Nrl^−/− n = 3–5 per group, NSG n = 4–8 recipients per group). Four slides of serial sections were quantified per eye