Fig. 3

Effect of hiPSC-EV and diPSC-EV administration on lung architecture. A Imaging of sections stained with H&E: hyperoxia-induced airspace enlargement is much improved following treatment with hiPSC-EVs; less significant improvement is noted with diPSC-EVs. B Comparative analysis of mean linear intercepts in the different groups (n = 3 in each group; and, for each tissue, 4 images were analyzed). One-way ANOVA was used for statistical analysis. *p ≤ 0.05. **p ≤ 0.01