Fig. 6
Effect of hiPSC-EV and diPSC-EV administration on Prdx5, Nfe2l2 and VEGFa gene expression, based on qRT-PCR results. Treatment with diPSC-EVs following hyperoxia exposure induced a significant upregulation of the antioxidant genes Prdx5 and Nfe2l2 expression, and also an increase in VEGFa expression. The effects of hiPSC-EVs on the expression of these genes were less pronounced. *p ≤ 0.05. **p ≤ 0.01. **p ≤ 0.0001