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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome

Fig. 5

Flow cytometric analysis of human monocytes educated with EVs or LPS-EVs produced by flasks or bioreactor. Monocytes from 3 isolates were educated with flask EVs (24H flask or 24H + LPS flask) from the F_1 MSC isolate, or bioreactor produced EVs (96H Bioreactor or 24H + LPS Bioreactor) from the B MSC isolate to generate flask EEMos, bioreactor EEMos, flask LPS-EEMos or bioreactor LPS-EEMos. Cells were analyzed by flow cytometry (N = 3 biological replicates). The percent (%) CD14+ cells for each marker (± SEM) is shown A CD86, HLA-DR, PD-L1 and CD163 B CD16, CD73 and CD206. Groups were compared by Kruskal–Wallis with a Dunn post-test *p < / = 0.05, ** p < / = 0.005, *** p < / = 0.0005 **** p < / = 0.0001 between groups is designated by bars as compared to control monocytes

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Stem Cell Research & Therapy

ISSN: 1757-6512