Fig. 3

Efficacy of hiPSC-CM patch transplantation in a porcine MI model: a preclinical trial. a: Change in cardiac function after transplantation of the hiPSC-CM patch in MI model pigs. LVEF, left ventricular ejection fraction; LVDd, left ventricular end-diastolic diameter; LVDs, left ventricular end-systolic diameter. Sham: n = 4, hiPSC-CM: n = 7. b: Representative images of endocardial systolic cardiac wall motion at the papillary muscle level 12 weeks after the implantation. (a) LAD (red), LCX (yellow), and RCA (green) regions. (b) Circumferential strains of sham and hiPSC-CM patches. c: Cardiac MRI was performed to compare the LV CS values at baseline and 12 weeks following treatment. Sham: n = 4, hiPSC-CM patch: n = 6. d: Pathological interstitial fibrosis 12 weeks following treatment. Left: Masson's trichrome staining of a porcine heart. Scale bar: 1 cm. Right: % area of fibrosis. Data are presented as the mean ± SD. sham: n = 4, hiPSC-CM patch: n = 6. *P < 0.05, **P < 0.01; ns, not significant.