Fig. 4

IMR and cytokine expression following transplantation of the hiPSC-CM patch in a porcine MI model. a, b: Schematic representation of IMR. ΔΙΜΡ was defined as IMR (postimplantation) − IMR (preimplantation). sham: n = 4, hiPSC-CM patch: n = 6 c: Upper panel, representative image of capillaries and arterioles immunostained with CD31 (red) and αSMA (green) at the infarct-border zone; lower panel, quantification of the number of CD31- and αSMA-positive cells. Each section was evaluated in 10 fields of view. Scale bar: 100 μm. sham: n = 4, hiPSC-CM patch: n = 6. d: Gene expression of proangiogenic factors in the infarct-border region 4 weeks following treatment. The myocardium around the infarct zone, which exhibited regional fibrosis, was excised and evaluated. Data are presented as the mean ± SD. Sham: n = 4, hiPSC-CM patch: n = 6, *P < 0.05