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Table 7 AP characteristics of Ctrl1, IEM and SFN neurons

From: How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessment

Parameters

Ctrl1

n

IEM

n

SFN

n

RMP, mV

− 72.2 ± 1.7

12

− 68.8 ± 1.3

21

− 69.3 ± 1.1

23

Cell capacitance, pF

19.1 ± 1.7

10

14.5 ± 0.8

17

19.6 ± 1.7

23

Threshold, pA

121 ± 16.3

10

31.1 ± 3.9*

17

47.4 ± 5.3*

23

AP threshold, mV

− 63.1 ± 1.4

10

− 58.0 ± 1.0*

17

− 54.5 ± 0.8*

23

AHP, mV

− 72.1 ± 1.4

10

− 75.0 ± 17.0

17

− 65.1 ± 0.9*

23

No. of APs (RAMP stimuli)

2.6 ± 1.3

12

5.0 ± 0.8

21

7.0 ± 1.1*

23

Time to 1st AP, ms

143.1 ± 29.0

5

63.0 ± 5.1*

20

64.5 ± 4.0*

19

  1. Data as Mean ± SEM
  2. *p < 0.05