Fig. 2
From: Efficacy and safety of mesenchymal stem cell therapy for ovarian ageing in a mouse model
Establishment of a natural ageing mouse model and evaluation of the therapeutic effects of MSCs on ovarian function. A The total number of follicles in the ovaries of the old and young groups. B The proportion of proliferating cells in the ovaries of the old and young groups. C Serum levels of oestradiol (E2) and follicle-stimulating hormone (FSH) in the old and young groups. D Representative images of vaginal smear staining. E Representative line charts of oestrous cycles in the old UC-MSC, old AD-MSC, old, old-saline and young groups. F The percent of time spent in the proestrus, estrus and metestrus/diestrus phases among the five groups. G The percent of proliferative cells based on Ki67 immunohistochemical staining of ovarian sections over 1 and 3 weeks after MSC transplantation. H Representative pathological images of Ki67 immunohistochemical staining of ovarian sections in each group over 1 week after transplantation. The error bars indicate SD. *p < 0.05