Fig. 7
From: Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3
PTX3 Stabilizes TSG6. A The mRNA levels of PTX3 and TSG6 were determined via qPCR after knocking-down PTX3 in CD317+ MSCs (n = 3). B The mRNA levels of PTX3 and TSG6 were determined via qPCR after over-expressing PTX3 in CD317− MSCs (n = 3). C Serum level of TSG6 and histology score in IBD mice treated with CD317+ MSCs knocking-down PTX3 (n = 8). D Serum level of TSG6 and histology score in IBD mice treated with CD317− MSCs over-expressing PTX3 (n = 8). E Serum level of TSG6 after intravenously injection of 1 μg TSG6 protein and 1 μg PTX3 protein (n = 8). F Proposed potential mechanism of upregulating PTX3 in CD317+ MSCs. *Indicates P < 0.05