Fig. 3
Medium and high doses of Cy cause long-term premature ovarian aging. A The rate of disorder estrous cycle disorders. B–E Serum levels of E2 (B), FSH (C), LH (D), and AMH (E) (n = 6). F–G Ovarian weights and indexes (n = 6). H–K The numbers of follicles in different levels (n = 6). L The numbers of total follicles (n = 6). M The numbers of atresia follicles (n = 6). N The structure of ovaries. a Representative primordial follicles, b Representative secondary follicles, c Representative antral follicles, and d Representative atresia follicles. Bar: 100 μm. * P < 0.05, ** P < 0.01, *** P < 0.001; **** P < 0.0001