Fig. 5
BMSCs-MOX restores hormone secretion and reduces the pathological changes in Cy-induced premature ovarian aging. A The process of BMSCs transplantation and moxibustion treatment. B The rate of estrous cycle disorder (n = 10, except for POI group [n = 8], BMSCs [n = 9]). C–F Serum levels of E2, FSH, LH, and AMH (n = 10, except for POI group [n = 8], BMSCs [n = 9]). G–H Ovarian weight and index (n = 10, except for POI group [n = 8], BMSCs [n = 9]). I–L The numbers of follicles in different levels (n = 6). M The numbers of total follicles (n = 6). N The numbers of atresia follicles (n = 6). O The structure of ovaries. ★ represents primordial follicles, ▲ represents secondary follicles. Bar: 100, 50 μm.* P < 0.05, ** P < 0.01, *** P < 0.001; **** P < 0.0001