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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy

Fig. 7

BMSCs-MOX attenuates mitochondrial damage by inhibiting the overactivated Pink1/Parkin-dependent mitophagy signaling pathway. A The process of treatment in each group. B DRP1, PINK1, and Parkin protein levels (n = 3). Full-length blots are presented in Additional file 4: Fig. S2. C Representative IHC for DRP1 and PINK1 (n = 6), Bar: 50 μm. D MODs of DRP1 and PINK1. EDrp1, Pink1, and Parkin mRNA expression (n = 6). F–G ROS release (n = 6). H Representative images of JC-1 and red/green ratio (Q2/Q3)(n = 3). I ATP concentration (n = 6). * p < 0.05, ** p < 0.01, *** p < 0.001; **** p < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512