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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy

Fig. 8

BMSCs-MOX improves ovarian function by inhibiting the overactivated Pink1/Parkin-dependent mitophagy signaling pathway. A The rate of estrous cycle disorder (CON group [n = 20], POI group [n = 15], Mdivi-1 group [n = 17], BMSCs-MOX group [n = 20], BMSCs-MOX-CCCP group [n = 16]). B–E Serum levels of E2, FSH, LH, AMH (n = 10). F–G Ovarian weights and indexes (n = 10). H–K The numbers of follicles in different levels (n = 6). L The numbers of total follicles (n = 6). M The numbers of atresia follicles (n = 6). N The structure of ovaries. Bar: 100 μm. * p < 0.05, ** p < 0.01, *** p < 0.001; **** p < 0.0001

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