Fig. 2

Study design: In vitro treatment and time of ectopic implantation in vivo. MSCs in passage 2 were subjected to chondrogenic induction in the presence of the BMP inhibitors CompA (500 nM), LDN21 (500 nM) or with DMSO used as control. Medium was exchanged three times a week. The PTHrP pulse group was treated with PTHrP (2.5 nM) for the last 6 h before daily medium exchange from day 7 onward. Its control group (Co) also received daily medium exchanges starting on day 7