Table 1 In vivo outcomes of wound healing augmented by mesenchymal stem cell therapy
From: Mesenchymal stem cell therapy for attenuation of scar formation during wound healing
Experimental details | Accelerated wound closure | Improved tissue strength | Prevented chronic ulceration | Improved visual appearance | Reference |
|---|---|---|---|---|---|
Murine MSC conditioned medium Topical delivery Splinted excisional wounds in mice | ✓ | [80] | |||
Allogenic and syngenic murine MSCs Injection into the wound Excisional wounds in mice | ✓ | [43] | |||
Murine MSCs Injection into the wound Excisional wounds in db/db mice | ✓ | ✓ | [116] | ||
Rat ASCs Injection into the wound Excisional wounds in diabetic rats | ✓ | ✓ | [117] | ||
Murine MSCs Injection into the wound margin Splinted excisional wounds in db/db mice | ✓ | ✓ | ✓ | [110] | |
Human MSCs Injection into wound Incisional wounds in rabbits | ✓ | ✓ | [118] | ||
Human V53/2 MSC cell line Seeded on collagen scaffolds Splinted excisional wounds in mice | ✓ | ✓ | [119] | ||
Human MSCs Incorporated in fibrin spray Chronic and acute wounds in humans | ✓ | ✓ | ✓ | [120] | |
Swine MSCs Injection into the wound Thermal wounds in mini pigs | ✓ | ✓ | [108] | ||
Murine MSCs Systemic injection Excisional wounds in mice | ✓ | [39] | |||
Rat MSCs Systemic injection Excisional wounds in rats | ✓ | ✓ | [121] |