From: Zebrafish erythropoiesis and the utility of fish as models of anemia
Human disease | Mutant | Gene | Function | Reference |
---|---|---|---|---|
Erythropoietic protoporphyria | dracula | Ferrochelatase | Enzyme functioning in heme synthesis | [50] |
Hemolytic anemia | merlot | Erythrocyte membrane protein 4.1R | Structural protein of erythrocyte membrane Stabilizes β-spectrin/actin interaction | [54] |
Congenital dyserythropoietic anemia type II (HEMPAS) | retsina | Solute carrier family 4 (anion exchanger 1a or band 3) | Chloride exchanger | [56] |
Hereditary spherocytosis | riesling | β-spectrin | Structural protein of erythrocyte membrane | [59] |
Congenital sideroblastic anemia | sauternes | Aminolevulinate synthetase 2 (alas2) | Enzyme functioning in heme synthesis | [63] |
Hypochromic anemia (resembles thalassemia) | zinfandel | Globin | Oxygen transport | [35] |
Type IV hemochromatosis | weissherbst | Ferroportin 1 | Iron transport | [65] |