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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade

Figure 6

Effect of heme oxygenase-1 (HO-1) induction and suppression on adipogenic marker expression in mesenchymal stem cell (MSC)-derived adipocytes. (A-C) Representative immunoblots and densitometry analysis of Wnt10b, p-Glycogen synthase kinase (GSK), β-catenin levels, respectively. Data are expressed as means ± SD (*P < 0.01 vs control, **P < 0.05 vs siRNA HO-1). (D-E) Effect of HO-1 induction and inhibition on Wnt -responsive genes IL-8 and Secreted frizzled-related protein 1 (SFRP1). Data are expressed as means ± SD (*P < 0.05 vs control, #P < 0.05 vs cobalt-protoporphyrin IX (CoPP)).

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Stem Cell Research & Therapy

ISSN: 1757-6512