Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells

Table 1 Representative preclinical animal studies using adipose-derived stromal/stem cells and stromal vascular fraction cells

Tissue type	Defect	Species	References
Adipose/soft tissue	Fat pad generation	Murine, rat, ovine	[51–60]
	Lipodystrophy	Murine	[48, 61]
	Burn/radiation trauma	Murine	[62–64]
Bone	Critical sized defect
	Craniofacial	Murine, rat	[65, 66]
	Long bone	Murine	[67]
	Spinal fusion	Rat	[68, 69]
Cardiac	Myocardial infarction	Murine, rat	[42, 43, 70, 71]
Central nervous system	Vascular injury/stroke	Murine, rat	[44, 46, 72]
	Spinal cord trauma	Rat	[47]
	Multiple sclerosis	Murine	[33]
Gastrointestinal tract	Crohn's disease/inflammatory bowel syndrome	Murine	[73]
Hematopoiesis	Bone marrow transplantation	Murine	[74, 75]
Joint	Osteoarthritis	Canine, caprine, equine	[76–79]
Liver	Acute toxicity/regeneration	Murine	[80–88]
Pancreas	Type 1 diabetes mellitus	Murine, rat	[48, 89, 90]
Renal	Acute ischemia	Rat	(JMG, unpublished)
Skin	Wounds, burns	Murine, porcine	[62, 64, 91]
Tendon	Tendonitis	Equine	[92]
Urinary bladder	Incontinence	Rat	[93]
Vascular	Hind limb ischemia	Murine, rat	[36, 41, 45]

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