Figure 1

Preventative administration of human cell therapy reduces the clinical score of myelin oligodendrocyte glycoprotein (35–55)-induced experimental autoimmune encephalitis. Improved clinical scores were seen in bone-derived marrow stromal cell (BMSC)-treated (n = 10), adipose stem cell (ASC)-treated (n = 12), and stromal vascular fraction (SVF)-treated (n = 12) mice compared with controls (n = 12). (A) Values are means from three independent reviewers. Bars, ± standard error of the mean. *P ≤ 0.05, comparing controls and treated mice. (B) The clinical scores at day 14 days post disease induction show the distribution during peak disease, demonstrating that the majority of treated mice displayed less severe symptoms (left panel). The clinical scores at the end of the course demonstrate that the treated groups stably maintained their reduced state of disease (right panel).