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  1. Research

    A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial

    Anal sphincter defects are a major cause of fecal incontinence causing negative effects on daily life, social interactions, and mental health. Because human adipose-derived stromal/stem cells (hADSCs) are easi...

    Arash Sarveazad, Graham L. Newstead, Rezvan Mirzaei, Mohammad Taghi Joghataei, Mehrdad Bakhtiari, Asrin Babahajian and Bahar Mahjoubi

    Stem Cell Research & Therapy 2017 8:40

    Published on: 21 February 2017

  2. Research

    Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells

    Magnesium is essential for numerous physiological functions. Magnesium exists mostly in bone and the amount is dynamically regulated by skeletal remodeling. Accelerating bone mass loss occurs when magnesium in...

    Yu-Tzu Tsao, Ya-Yi Shih, Yu-An Liu, Yi-Shiuan Liu and Oscar K. Lee

    Stem Cell Research & Therapy 2017 8:39

    Published on: 21 February 2017

  3. Research

    Mesenchymal stem cells alleviate Japanese encephalitis virus-induced neuroinflammation and mortality

    Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. Japanese encephalitis (JE) caused by JEV is characterized by extensive inflammatory cytokine secretion, microglia activatio...

    Peiyu Bian, Chuantao Ye, Xuyang Zheng, Jing Yang, Wei Ye, Yuan Wang, Yun Zhou, Hongwei Ma, Peijun Han, Hai Zhang, Ying Zhang, Fanglin Zhang, Yingfeng Lei and Zhansheng Jia

    Stem Cell Research & Therapy 2017 8:38

    Published on: 16 February 2017

  4. Research

    In vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells

    First trimester (FTM) and term human umbilical cord-derived perivascular cells (HUCPVCs), which are rich sources of mesenchymal stem cells (MSCs), can give rise to Sertoli cell (SC)-like as well as haploid ger...

    Ekaterina Shlush, Leila Maghen, Sonja Swanson, Shlomit Kenigsberg, Sergey Moskovtsev, Tanya Barretto, Andrée Gauthier-Fisher and Clifford L. Librach

    Stem Cell Research & Therapy 2017 8:37

    Published on: 15 February 2017

  5. Research

    Cardiosphere-derived cells do not improve cardiac function in rats with cardiac failure

    Heart failure represents an important public health issue due to its high costs and growing incidence worldwide. Evidence showing the regenerative potential of postmitotic heart tissue has suggested the existe...

    Taís Hanae Kasai-Brunswick, Andréa Rodrigues da Costa, Raiana Andrade Quintanilha Barbosa, Bruna Farjun, Fernanda Cristina Paccola Mesquita, Danúbia Silva dos Santos, Isalira Peroba Ramos, Grazielle Suhett, Guilherme Visconde Brasil, Sandro Torrentes da Cunha, José Oscar R. Brito, Juliana do Amaral Passipieri, Adriana Bastos Carvalho and Antonio Carlos Campos de Carvalho

    Stem Cell Research & Therapy 2017 8:36

    Published on: 15 February 2017

  6. Research

    Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling

    Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplas...

    Gesheng Cheng, Xingye Wang, Yongxin Li and Lu He

    Stem Cell Research & Therapy 2017 8:34

    Published on: 10 February 2017

  7. Research

    GMP-conformant on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration

    CD133+ stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. Several clinical trials have shown remarkable beneficial effects following their intramyoc...

    Anna Skorska, Paula Müller, Ralf Gaebel, Jana Große, Heiko Lemcke, Cornelia A. Lux, Manuela Bastian, Frauke Hausburg, Nicole Zarniko, Sandra Bubritzki, Ulrike Ruch, Gudrun Tiedemann, Robert David and Gustav Steinhoff

    Stem Cell Research & Therapy 2017 8:33

    Published on: 10 February 2017

  8. Research

    Differential long noncoding RNA/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells

    Mesenchymal stem cells (MSCs) are the most promising cell types for bone regeneration and repair due to their osteogenic potential. MSC differentiation is precisely regulated and orchestrated by the mechanical...

    Wenyuan Zhang, Rui Dong, Shu Diao, Juan Du, Zhipeng Fan and Fu Wang

    Stem Cell Research & Therapy 2017 8:30

    Published on: 7 February 2017

  9. Research

    Endothelial differentiation of bone marrow mesenchyme stem cells applicable to hypoxia and increased migration through Akt and NFκB signals

    Bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are used to repair hypoxic or ischemic tissue. However, the underlining mechanism of resistance in the hypoxic microenvironment...

    Cheng Liu, An-Ly Tsai, Ping-Chia Li, Chia-Wei Huang and Chia-Ching Wu

    Stem Cell Research & Therapy 2017 8:29

    Published on: 7 February 2017

  10. Research

    Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis

    The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine p...

    Anwar Abdalmula, Laura M. Dooley, Claire Kaufman, Elizabeth A. Washington, Jacqueline V. House, Barbara A. Blacklaws, Peter Ghosh, Silviu Itescu, Simon R. Bailey and Wayne G. Kimpton

    Stem Cell Research & Therapy 2017 8:22

    Published on: 7 February 2017

  11. Research

    Characteristics of human adipose derived stem cells in scleroderma in comparison to sex and age matched normal controls: implications for regenerative medicine

    Adipose-derived stem cells (ADSCs) are emerging as an alternative stem cell source for cell-based therapies. Recent data suggest that autologous ADSC-enriched micrografting improves the effects of facial invol...

    Michelle Griffin, Caroline M. Ryan, Omar Pathan, David Abraham, Christopher P. Denton and Peter E. M. Butler

    Stem Cell Research & Therapy 2017 8:23

    Published on: 7 February 2017

  12. Research

    Phenotype and multipotency of rabbit (Oryctolagus cuniculus) amniotic stem cells

    Stem cells are capable of unlimited self-renewal and are able to remain undifferentiated for extended periods of time prior to their differentiation into specific cell lineages. Because of the issues (ethical ...

    Jéssica Borghesi, Lara Carolina Mario, Ana Claudia Oliveira Carreira, Maria Angélica Miglino and Phelipe Oliveira Favaron

    Stem Cell Research & Therapy 2017 8:27

    Published on: 7 February 2017

  13. Research

    CCL11 promotes migration and proliferation of mouse neural progenitor cells

    Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenito...

    Feifei Wang, Nobuyasu Baba, Yuan Shen, Tatsuyuki Yamashita, Emi Tsuru, Masayuki Tsuda, Nagamasa Maeda and Yusuke Sagara

    Stem Cell Research & Therapy 2017 8:26

    Published on: 7 February 2017

  14. Research

    Restored in vivo-like membrane lipidomics positively influence in vitro features of cultured mesenchymal stromal/stem cells derived from human placenta

    The study of lipid metabolism in stem cell physiology has recently raised great interest. The role of lipids goes beyond the mere structural involvement in assembling extra- and intra-cellular compartments. Ne...

    Alexandros Chatgilialoglu, Martina Rossi, Francesco Alviano, Paola Poggi, Chiara Zannini, Cosetta Marchionni, Francesca Ricci, Pier Luigi Tazzari, Valentina Taglioli, Philip C. Calder and Laura Bonsi

    Stem Cell Research & Therapy 2017 8:31

    Published on: 7 February 2017

  15. Research

    An effective ex-vivo approach for inducing endothelial progenitor cells from umbilical cord blood CD34+ cells

    Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and f...

    Meng Qin, Xin Guan, Huihui Wang, Yu Zhang, Bin Shen, Qingyu Zhang, Wei Dai, Yupo Ma and Yongping Jiang

    Stem Cell Research & Therapy 2017 8:25

    Published on: 7 February 2017

  16. Research

    The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury

    Mesenchymal stromal cells (MSCs) and renal stem/progenitors improve the recovery of acute kidney injury (AKI) mainly through the release of paracrine mediators including the extracellular vesicles (EVs). Sever...

    Andrea Ranghino, Stefania Bruno, Benedetta Bussolati, Aldo Moggio, Veronica Dimuccio, Marta Tapparo, Luigi Biancone, Paolo Gontero, Bruno Frea and Giovanni Camussi

    Stem Cell Research & Therapy 2017 8:24

    Published on: 7 February 2017

  17. Research

    Rational transplant timing and dose of mesenchymal stromal cells in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials

    Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing a...

    Zi Wang, Lingling Wang, Xuan Su, Jun Pu, Meng Jiang and Ben He

    Stem Cell Research & Therapy 2017 8:21

    Published on: 28 January 2017

  18. Research

    Intramuscular injection of human umbilical cord-derived mesenchymal stem cells improves cardiac function in dilated cardiomyopathy rats

    Stem cells provide a promising candidate for the treatment of the fatal pediatric dilated cardiomyopathy (DCM). This study aimed to investigate the effects of intramuscular injection of human umbilical cord-de...

    Chenggang Mao, Xu Hou, Benzhen Wang, Jingwei Chi, Yanjie Jiang, Caining Zhang and Zipu Li

    Stem Cell Research & Therapy 2017 8:18

    Published on: 28 January 2017

  19. Research

    Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction

    Transplantation of cardiosphere-derived cells (CDCs) has been shown to exert a therapeutic effect in patients with myocardial infarction (MI). However, poor survival of transplanted CDCs limits their beneficia...

    Rongchuan Yue, Wenbin Fu, Xiang Liao, Cong Lan, Qiao Liao, Liangpeng Li, Dezhong Yang, Xuewei Xia, Xiongwen Chen, Chunyu Zeng and Wei Eric Wang

    Stem Cell Research & Therapy 2017 8:17

    Published on: 28 January 2017

  20. Research

    Two-photon FLIM of NAD(P)H and FAD in mesenchymal stem cells undergoing either osteogenic or chondrogenic differentiation

    Metabolic plasticity and the versatility of different lineages of stem cells as they satisfy their energy demands are not completely understood. In this study we investigated the metabolic changes in mesenchym...

    Aleksandra V. Meleshina, Varvara V. Dudenkova, Alena S. Bystrova, Daria S. Kuznetsova, Marina V. Shirmanova and Elena V. Zagaynova

    Stem Cell Research & Therapy 2017 8:15

    Published on: 28 January 2017

  21. Research

    Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy

    The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis (HS), inhibits the end...

    Fernando Ezquer, Javiera Bahamonde, Ya-Lin Huang and Marcelo Ezquer

    Stem Cell Research & Therapy 2017 8:20

    Published on: 28 January 2017

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