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  1. Research

    A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

    Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorde...

    Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding and Yongping Jiang

    Stem Cell Research & Therapy 2017 8:169

    Published on: 18 July 2017

  2. Research

    Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia

    Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration o...

    Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik and Ivan Vulev

    Stem Cell Research & Therapy 2017 8:165

    Published on: 12 July 2017

  3. Research

    Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro

    Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury and are possibly attracted by inflammatory factors. As a proinflammatory mediator, angiotensin II (Ang II) reportedly enhances the m...

    Xiu-ping Xu, Hong-li He, Shu-ling Hu, Ji-bin Han, Li-li Huang, Jing-yuan Xu, Jian-feng Xie, Ai-ran Liu, Yi Yang and Hai-bo Qiu

    Stem Cell Research & Therapy 2017 8:164

    Published on: 12 July 2017

  4. Research

    Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells

    Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where pancreatic beta cells are lost before the clinical manifestations of the disease. Administration of mesenchymal stem cells (MSCs) or MSCs dif...

    Anshu Sharma and Rajni Rani

    Stem Cell Research & Therapy 2017 8:167

    Published on: 12 July 2017

  5. Research

    Isolation and characterization of equine endometrial mesenchymal stromal cells

    Equine mesenchymal stromal/stem cells (MSCs) are most commonly harvested from bone marrow (BM) or adipose tissue, requiring the use of surgical procedures. By contrast, the uterus can be accessed nonsurgically...

    B. Elisabeth Rink, Karin R. Amilon, Cristina L. Esteves, Hilari M. French, Elaine Watson, Christine Aurich and F. Xavier Donadeu

    Stem Cell Research & Therapy 2017 8:166

    Published on: 12 July 2017

  6. Research

    Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α

    Blood-brain barrier impairment is a major indicator of endothelial dysfunction in diabetes. Studies showed that endothelial progenitor cell (EPC) transplantation promoted angiogenesis and improved function rec...

    Jieli Geng, Liping Wang, Meijie Qu, Yaying Song, Xiaojie Lin, Yajing Chen, Muyassar Mamtilahun, Shengdi Chen, Zhijun Zhang, Yongting Wang and Guo-Yuan Yang

    Stem Cell Research & Therapy 2017 8:163

    Published on: 11 July 2017

  7. Research

    Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

    The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available ...

    Léonore Avercenc-Léger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sébastien Hupont, Rachid Rahouadj, Jacques Magdalou, Jean-François Stoltz, Danièle Bensoussan, Céline Huselstein and Loïc Reppel

    Stem Cell Research & Therapy 2017 8:161

    Published on: 5 July 2017

  8. Research

    Overexpression of c-Met in bone marrow mesenchymal stem cells improves their effectiveness in homing and repair of acute liver failure

    Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has emerged as a novel therapy for acute liver failure (ALF). However, the homing efficiency of BMSCs to the injured liver sites appears to...

    Kun Wang, Yuwen Li, Tiantian Zhu, Yongting Zhang, Wenting Li, Wenyu Lin, Jun Li and Chuanlong Zhu

    Stem Cell Research & Therapy 2017 8:162

    Published on: 5 July 2017

  9. Research

    Global gene expression profiling and senescence biomarker analysis of hESC exposed to H2O2 induced non-cytotoxic oxidative stress

    Human embryonic stem cells (hESCs) potentially offer new routes to study, on the basis of the Developmental Origins of Health and Disease (DOHaD) concept, how the maternal environment during pregnancy influenc...

    Maria Barandalla, Hui Shi, Hui Xiao, Silvia Colleoni, Cesare Galli, Pietro Lio, Matthew Trotter and Giovanna Lazzari

    Stem Cell Research & Therapy 2017 8:160

    Published on: 5 July 2017

  10. Research

    Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model

    Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might at...

    An Martens, Sofie Ordies, Bart M. Vanaudenaerde, Stijn E. Verleden, Robin Vos, Dirk E. Van Raemdonck, Geert M. Verleden, Valerie D. Roobrouck, Sandra Claes, Dominique Schols, Eric Verbeken, Catherine M. Verfaillie and Arne P. Neyrinck

    Stem Cell Research & Therapy 2017 8:159

    Published on: 5 July 2017

  11. Review

    Cultured epidermal stem cells in regenerative medicine

    Transplantation of cultured epidermal cell sheets (CES) has long been used to treat patients with burns, chronic wounds, and stable vitiligo. In patients with large area burns this can be a life-saving procedu...

    Catherine J. Jackson, Kim Alexander Tønseth and Tor Paaske Utheim

    Stem Cell Research & Therapy 2017 8:155

    Published on: 4 July 2017

  12. Research

    Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo

    The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration...

    Beverley J. Cottle, Fiona C. Lewis, Victoria Shone and Georgina M. Ellison-Hughes

    Stem Cell Research & Therapy 2017 8:158

    Published on: 4 July 2017

  13. Research

    Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds

    The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and innovative treatments to reduce the bacterial load in cut...

    Rebecca M. Harman, Steven Yang, Megan K. He and Gerlinde R. Van de Walle

    Stem Cell Research & Therapy 2017 8:157

    Published on: 4 July 2017

  14. Research

    Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells

    Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However,...

    Yanhui Li, Yan Wen, Morgaine Green, Elise K. Cabral, Prachi Wani, Fan Zhang, Yi Wei, Thomas M. Baer and Bertha Chen

    Stem Cell Research & Therapy 2017 8:156

    Published on: 4 July 2017

  15. Research

    Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis

    Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance. Hashimot...

    Antonina Coppola, Laura Tomasello, Maria Pitrone, Salvatore Cillino, Pierina Richiusa, Giuseppe Pizzolanti and Carla Giordano

    Stem Cell Research & Therapy 2017 8:154

    Published on: 3 July 2017

  16. Research

    Human umbilical cord stem cell conditioned medium versus serum-free culture medium in the treatment of cryopreserved human ovarian tissues in in-vitro culture: a randomized controlled trial

    To reduce young female fertility loss, the in-vitro culture of cryopreserved ovarian cortical tissues (OCTs) is considered an effective approach without delaying treatment and undergoing stimulation medicine. ...

    Yingxian Jia, Xiaohan Shi, Yidong Xie, Xiaochuan Xie, Yan Wang and Shangwei Li

    Stem Cell Research & Therapy 2017 8:152

    Published on: 24 June 2017

  17. Review

    Interplay between craniofacial stem cells and immune stimulus

    Craniofacial mesenchymal stem cells (MSCs), isolated from an abundant and accessible source of craniofacial tissues, possess self-renewal and multilineage differentiation potential. It has been reported that c...

    Ruili Yang, Tingting Yu and Yanheng Zhou

    Stem Cell Research & Therapy 2017 8:147

    Published on: 24 June 2017

  18. Research

    Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells

    Polycaprolactone (PCL) has been regarded as a promising synthetic material for bone tissue engineering application. Owing to its unique biochemical properties and great compatibility, PCL fibers have come to b...

    Ruyue Xue, Yuna Qian, Linhao Li, Guidong Yao, Li Yang and Yingpu Sun

    Stem Cell Research & Therapy 2017 8:148

    Published on: 24 June 2017

  19. Research

    The morphological regeneration and functional restoration of bladder defects by a novel scaffold and adipose-derived stem cells in a rat augmentation model

    Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladde...

    Qiong Wang, Dong-dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang and Mu-Jun Lu

    Stem Cell Research & Therapy 2017 8:149

    Published on: 24 June 2017

  20. Research

    Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

    Asthma is a chronic inflammatory disease that can be difficult to treat due to its complex pathophysiology. Most current drugs focus on controlling the inflammatory process, but are unable to revert the change...

    Ligia Lins de Castro, Debora Gonçalves Xisto, Jamil Zola Kitoko, Fernanda Ferreira Cruz, Priscilla Christina Olsen, Patricia Albuquerque Garcia Redondo, Tatiana Paula Teixeira Ferreira, Daniel Jay Weiss, Marco Aurélio Martins, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco

    Stem Cell Research & Therapy 2017 8:151

    Published on: 24 June 2017

  21. Research

    Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells

    Disorders of the oxidative phosphorylation (OXPHOS) system represent a large group among the inborn errors of metabolism. The most frequently observed biochemical defect is isolated deficiency of mitochondrial...

    Marlen Melcher, Katharina Danhauser, Annette Seibt, Özer Degistirici, Fabian Baertling, Arun Kumar Kondadi, Andreas S. Reichert, Werner J. H. Koopman, Peter H. G. M. Willems, Richard J. Rodenburg, Ertan Mayatepek, Roland Meisel and Felix Distelmaier

    Stem Cell Research & Therapy 2017 8:150

    Published on: 24 June 2017

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