Figure 3From: Role of whole bone marrow, whole bone marrow cultured cells, and mesenchymal stem cells in chronic wound healing Classical and reverse model of wounding procedure in mice. (A) Diagram with classical and reverse wound model procedure. In the classical model the 8 mm punch is made 30 days after irradiation and in the reverse model the 8 mm punch is created between the two cycles of radiation. (B) Wound healing is expressed as percentage closure relative to original size (1-(wound area on day x)/(wound area on day 0)) x100. The reverse model showed lower percentage closure at all time points compared to the classical model. P <0.05 indicates a statistically significant difference in wound area between the reverse and classical models. All values are expressed as the mean and SEM. Each group comprised 12 animals (n = 12). SEM, standard error of the mean.Back to article page