Effects of WBM, BMC and MSC on the
wound closure in the mouse model and analysis of wounds. (A) Representative photographs of the mouse excisional reverse model after transplantations of BMC, WBM, MSC and control vehicle at 0, 7 and 15 days. (B) Epithelialization for each group after transplantations of BMC, WBM, MSC and control vehicle is expressed as percentage closure relative to the original size (1-(wound area on day x)/(wound area on day 0)) x100. WBM treated wounds featured greater percentage closure at all time points compared to BMC and MSC. Data represent mean +/− SEM of five measurements. Each group comprised 12 animals (n = 12). P <0.01 indicates a statistically significant difference in wound closure between animals treated with WBM or BMC compared to animals treated with MSC and control group. BMC, whole bone marrow cultured cells; MSC, mesenchymal stem cells; SEM, standard error of the mean; WBM, whole bone marrow.