Figure 7

B-CB-P grafts enabled stable nasal augmentation in vivo. (A to D) Nasal augmentation regenerated by cell brick-enriched PRP gel composited with BMSCs. (E to H) Histological analysis including HE, safranin-O, Masson’s trichrome staining and COL-II immunostaining of the cross-sections further revealed that the samples formed homogeneous cartilage-like tissue with abundant lacunae as well as strong positive staining of GAG and type II collagen without ossification, and higher magnification for the above staining (I to L); bar = 200 μm, magnification × 40 (E to H) and bar = 50 μm, magnification × 200 (I to L). B-CB-P, BMSCs–cell bricks–PRP; BMSC, bone marrow-derived mesenchymal stem cell; COL, collagen; HE, hematoxylin and eosin; PRP, platelet-rich plasma; GAG, glycosaminoglycan.