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Table 1 Patient demographics and pre-operative characteristics

From: Clinical outcomes of xeno-free expansion and transplantation of autologous ocular surface epithelial stem cells via contact lens delivery: a prospective case series

Case. age at last follow-up,years/Sex

Eye, R/L

LSCD, unilateral/bilateral

Days in culture

LSCD, partial/total

Aetiology of LSCD

Previous procedures

Post-operative topical therapy

Post-operative immunosuppressive or systemic ocular therapy or both

1. 40/M

R

B

14

T

Aniridia

Limbal tissue allograft + SK*, CE/IOL

FML, cellufresh tears, timolol

Minocycline 50 mg, mycophenolate mofetil 500 mg BD

2. 77/F

R

U

10

T

Primary acquired melanosis; multiple surgeries/topical mitomycin C therapy

Multiple conjunctival excisions

Predsol minims

Nil

3. 73/F

R

U

10

T

Recurrent melanoma; multiple surgeries

Multiple conjunctival excisions, cryotherapy, lid repair, HAM transplant

Cellufresh tears, dexa minims

Nil

4. 68/M

L

B

11

P

Query trachoma-induced

Ptosis repair

Cellufresh tears, dexa minims

Nil

5. 61/M

R

U

9

T

Chemical burn

Limbal tissue allograft*

Dexa minims

Doxcycline 100 mg

6. 65/F

R

B

16

T

Aniridia

2xPK*, cyclodiode laser

Dexa minims, timolol

Nil

7. 33/M

L

U

14

T

Chemical burn

HAM transplant + nexagon application*

Dexa minims

Nil

8. 50/M

L

U

14

T

Chemical burn

Ptosis repair, PK*, limbal tissue allograft + PK*, CE/IOL

Dexa minims, atropine sulphate 1% minims

Prednisone 80 mg in a tapering regime

9. 52/M

R

U

14

P

Query trachoma-induced

Removal of pseudopterygium

Dexa minims

Nil

10. 72/F

L

B

14

T

Aniridia

CE/IOL, ectropion repair, EDTA

Bimatoprost 0.03%, minims pilocarpine nitrate 2%, refresh tears

Acetazolamide 125 mg BD

11. 62/M

R

B

15

T

Multiple surgeries

PTK, PK (for corneal ectasia), CE/IOL

Dexa minims

Nil

12. 81/M

L

U

14

T

Chemical burn

Nil

Atropine sulphate 1% minims, timolol/latanoprost, dexa minims

Nil

13. 28/M

R

U

9

T

Chemical burn

BV diathermy

Dexa minims

Nil

14. 65/F

L

B

16

T

CL over-wear

PK*, CE/IOL, PK + limbal tissue allograft* + tarsorrhaphy, DSEK

Predsol minims, latanoprost/timolol, atropine sulphate 1% minims

Nil

15. 85/M

R

U

14

P

Limbal tumor excision; limbal surgeries

CE/IOL

Dexa minims, FML

Nil

16. 80/F

R

B

9

T

Cicatrising conjunctivitis; ocular surface toxicity from glaucoma medication

CE/IOL, blepharoplasty

Dexa minims, cellufresh tears, timolol/latanoprost

Nil

  1. All patients were additionally prescribed minims chloramphenicol 0.5% post-operatively (not included in table). Asterisk (*) indicates previous surgical procedures to treat limbal stem cell deficiency (LSCD). Days in culture refers to the time to establish a reasonable number of cells on the contact lens before transplantation. BD, twice daily dosing; BV, blood vessel; CE/IOL, cataracts extraction/intraocular lens insertion; cellufresh tears, preservative free carboxymethylcellulose sodium 5 mg/mL; CL, contact lens; dexa minims, minims dexamethasone sodium phosphate 0.1%; DSEK, Descemet’s stripping endothelial keratoplasty; EDTA, ethylenediaminetetraacetic acid chelation therapy for band keratopathy; FML, flurometholone 1%; HAM, human amniotic membrane; PK, penetrating keratoplasty; predsol minims, minims prednisolone sodium phosphate 0.5%; PTK, phototherapuetic keratectomy;refresh tears, preservative free polyvinyl alcohol 1.4%; SK, superficial keratectomy.