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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice

Figure 5

Intrasplenic and intrapancreatic adipose tissue-derived mesenchymal stem cell administrations do not change the frequency of regulatory T cells in the spleen and pancreatic lymph nodes of diabetic mice 70 days after cell transplantation. Frequency of regulatory CD4+CD25+Foxp3+ T (Treg) cells was analyzed by flow cytometry in cell suspensions obtained from the (A, C) spleen and (B, D) pancreatic lymph nodes (PLN) from adipose tissue-derived mesenchymal stem cell (ADMSC)-treated and phosphate-buffered saline (PBS)-treated mice. Cells were stained for surface markers CD4 and CD25 and subsequently for the transcription factor Foxp3. Bars represent average ± standard error of the mean. Intrasplenic route: Control-PBS, n = 5; R-ADMSCs, n = 7; NR-ADMSCs, n = 3. Intrapancreatic route: Control-PBS, n = 5; R-ADMSCs, n = 5; NR-ADMSCs, n = 7. NR-ADMSCs, nonresponder ADMSC-treated mice; R-ADMSCs, responder ADMSC-treated mice.

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Stem Cell Research & Therapy

ISSN: 1757-6512