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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy

Figure 2

Effects of psychosine on cell viability and galactocerebrosidase (GALC) activity. (A) TwS1 cells, oligodendrocyte progenitor cells (OPCs), and terminally differentiated oligodendrocytes were treated with psychosine at concentrations varying from 10 to 80 μM. Compared with TwS1 cells and terminally differentiated oligodendrocytes, OPCs had a higher threshold for psychosine toxicity. The cell viability of OPCs decreased dramatically at 80 μM. (B) GALC activity was measured in TwS1, OPCs, and terminally differentiated oligodendrocytes. The GALC level of OPCs and terminally differentiated oligodendrocytes was significant higher than that of TwS1, and the differences were statistically significant (both P <0.05). There was no difference between OPCs and terminally differentiated oligodendrocytes in GALC level (P >0.05). ES, embryonic stem.

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