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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Interaction between mesenchymal stem cells and endothelial cells restores endothelial permeability via paracrine hepatocyte growth factor in vitro

Figure 6

Hepatocyte growth factor (HGF) neutralisation attenuated the restoration of the integrity of human pulmonary microvascular endothelial cell (HPMEC) monolayers in mesenchymal stem cell-endothelial cell (MSC-EC) interaction conditions. We found that the paracellular and transcellular permeability in the anti-HGF antibody (Ab) group was significantly increased over control (without anti-HGF Ab) (nā€‰=ā€‰3, P <0.05) (A, B), suggesting that human MSCs restored the integrity of HPMEC monolayers in MSC-EC interaction by paracrine HGF. (n=3, ** p < 0.01 vs. group LPS; # p<0.05 # # p < 0.01 vs. group MSC-EC interaction) LPS, lipopolysaccharide.

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