Figure 7From: Interaction between mesenchymal stem cells and endothelial cells restores endothelial permeability via paracrine hepatocyte growth factor in vitro Hepatocyte growth factor (HGF) secreted by human mesenchymal stem cells (hMSCs) following mesenchymal stem cell-endothelial cell (MSC-EC) interactions upregulated vascular endothelial (VE)-cadherin protein and decreased caveolin-1 protein expression. Compared with the MSC group, MSC-EC interaction increased VE-cadherin protein expression (P <0.01) (A, C) while reducing caveolin-1 protein expression in human pulmonary microvascular endothelial cells (HPMECs) (P <0.01) (B, D). However, the MSC effect was significantly blocked by anti-HGF antibody (P <0.05 or P <0.01) (C, D). These results indicated that HGF secreted by hMSCs upregulated endothelial VE-cadherin protein and decreased caveolin-1 protein expression. (n=3, * *p < 0.01 vs. group LPS, # p < 0.01 vs. MSC; & p< 0.05 && p < 0.01 vs. group MSC-EC interaction) LPS, lipopolysaccharide.Back to article page