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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Figure 4

Slowly activating delayed rectifier potassium channel measured in human induced pluripotent stem cell cardiomyocytes. (A) Slowly activating delayed rectifier potassium channel (IKs) currents recorded in patient and control human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs). IKs currents were validated as Chromanol 293B-sensitive IKs currents (after subtraction). Averaged peak and tail current density (pA/pF) in patient and control hiPSC-CMs (right). Values are mean ± standard error of the mean (SEM; n = 7 for patient and control). *P <0.05, versus control. (B) IKs measured in iCell Cardiomyocyte (Cellular Dynamics International Inc., Madison, WI, USA), family control and patient hiPSC-CMs treated with ML277 (left). Averaged tail current density (pA/pF) of iCell, family control and patient hiPSC-CMs (right). Values are mean ± SEM. *P <0.05, versus baseline. LQT1, type 1 long QT syndrome.

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Stem Cell Research & Therapy

ISSN: 1757-6512