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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Figure 6

Action potential properties of human induced pluripotent stem cell cardiomyocytes. (A) Traces of spontaneous action potentials measured in ventricular-like, atrial-like, and nodal-like human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) derived from control and patient human induced pluripotent stem cells (hiPSCs; upper panel). Traces of paced (1 Hz) action potentials measured in ventricular-like, atrial-like, and nodal-like hiPSC-CMs derived from control and patient hiPSCs (lower panel). (B) Traces of spontaneous (upper panel) and paced (1 Hz) (lower panel) action potentials measured in iCell Cardiomyocyte (Cellular Dynamics International Inc., Madison, WI, USA), family control and patient ventricular-like hiPSC-CMs at baseline (solid lines) and post ML277 treatment (dashed lines). Horizontal dashed lines crossing the AP traces indicate a voltage of 0 mV. LQT1, type 1 long QT syndrome; SP, spontaneous.

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