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Figure 7 | Stem Cell Research & Therapy

Figure 7

From: Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Figure 7

Effects of Chromanol 293B on slowly activating delayed rectifier potassium channel and APD in ML277 treated human induced pluripotent stem cell cardiomyocytes. (A) Effects of Chromanol 293B on slowly activating delayed rectifier potassium channel in ML277-treated iCell Cardiomyocyte (Cellular Dynamics International Inc., Madison, WI, USA), family control and LQT1 human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs). (B) Effects of Chromanol 293B on action potential duration in ML277-treated iCell, family control and LQT1 hiPSC-CMs. *P <0.05, versus control; ^P <0.05, versus ML277 treated. APD50, action potential duration at 50% repolarization; APD90, action potential duration at 90% repolarization; LQT1, type 1 long QT syndrome; pA/pF, averaged peak and tail current density.

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Stem Cell Research & Therapy

ISSN: 1757-6512