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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction

Figure 5

Intra-myocardial injection of unfractioned and migration-enriched bone marrow mononuclear cells (BM-MNCs) improves echocardiography endpoints in a immune-deficient mouse model of myocardial infarction. Bar graphs show the effect of unfractioned, stromal cell-derived factor 1 (SDF-1) migrated (migr) or non-migrated (non) BM-MNCs from three different donors on (A-I) indexes of contractility and (J,K) intraventricular pressure in immunodeficient mice with myocardial infarction. N = 14 mice per group for all the measured indexes. *P < 0.05, **P < 0.01, ***P < 0.001, versus vehicle; Φ P < 0.05, ΦΦ P < 0.01, ΦΦΦ P < 0.001, versus unfractioned BM-MNCs; ## P < 0.01, versus non-migrated BM-MNCs. CO, cardiac output; dP/dt, maximum changes in developed pressure; LVAWd, left ventricular anterior wall thickness in diastole; LVAWs, left ventricular anterior wall thickness in systole; LVEDP, left ventricular end diastolic pressure; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end systolic volume; LVPWd, left ventricular posterior wall thickness in diastole; LVPWs, left ventricular posterior wall thickness in systole; SV, stroke volume.

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