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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities

Figure 2

Extensive mouse hepatocyte proliferation after administration of diphtheria toxin. Immunofluorescent staining for cell proliferation markers Ki67 (A) and BrdU (B) in liver tissues from 8-week-old Alb-TRECK/SCID mice without and with diphtheria toxin (DT) treatment. DT-treated mouse liver with serum aspartate aminotransferase activity of 12,000 IU/L was sampled at 48 hours. At 2 hours before sampling, BrdU (50 mg/kg) was administered intraperitoneally. Experiments were performed with five mice/group, and representative images are shown. Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI). Scale bars = 100 μm.

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