Skip to main content
Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities

Figure 5

Expressions of human hepatocyte-related genes in human primary fetal liver cell- and human hepatic stem cell-derived humanized livers. (A) Results of quantitative PCR for the expression of functional hepatocyte markers, including hALB, hAFP, hCYP3A4, hCYP2C9, and hCYP2C19, in samples taken before and about 8 weeks after human primary fetal liver cell (FLC) and human hepatic stem cell (HpSC) transplantation. Results are mean ± standard error of the mean (n ≥ 4 mice/group). (B) Heat maps for 83 human-specific drug metabolism genes and transcription factors, shown separately for independent experiments to analyze human primary FLCs and HpSCs before and at 8 weeks after cell transplantation. Human adult hepatocytes were used as a positive control. AH, adult hepatocyte; ND, not detectable; Sham, mice transplanted with saline.

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512