Figure 11
Growth model predictions of population expansion after 12 days of culture for different mitigation strategies. Model predictions are shown for 24-well-plate wells of initial media height h 0 = 1 mm (red bars) and h 0 = 5 mm (blue bars), corresponding to 0.2 ml and 0.5 ml culture volumes respectively. The fed-batch growth model is defined by Equations (14) to (18), (24) and (25) in Additional file 1, and the perfusion growth model by Equations (14) to (18) and (25) to (27) in Additional file 1. The diffusivity D = 6.5 × 10−11 m2/second, the initial conditions for the growth model are defined in Equation (30), and the parameters are presented in Table 2.