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Table 1 Physical properties of known haemopoietic stem cell inhibitory factors

From: Predictions for optimal mitigation of paracrine inhibitory signalling in haemopoietic stem cell cultures

Inhibitory factor

Molecular weight (kDa)

Diffusivity (m 2 /second)

TGF-β

26

6.43 × 10−11

TNFSF9

23.8

6.76 × 10−11

MIP-1α

8

1.23 × 10−10

MIP-1β

8

1.23 × 10−10

IP-10

9

1.16 × 10−10

NAP-2

8

1.23 × 10−10

SPARC

40

5.07 × 10−11

PDGF-CC

13.4

9.28 × 10−11

  1. The diffusivity is calculated using the formula D = 1.72 × 10−8(MW)−0.552 [32,33]. IP, interferon gamma induced protein; MIP, macrophage inhibitory protein; MW, molecular weight; NAP, neutrophil activating protein; PDGF, platelet-derived growth factor; SPARC, secreted protein, acidic and rich in cysteine; TGF-β, transforming growth factor beta; TNF, tumour necrosis factor.
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Stem Cell Research & Therapy

ISSN: 1757-6512