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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Multiple intravenous injections of allogeneic equine mesenchymal stem cells do not induce a systemic inflammatory response but do alter lymphocyte subsets in healthy horses

Figure 2

Multiple allogeneic mesenchymal stem cell (MSC) injections do not induce a systemic cytokine response. Serum concentration of pro-inflammatory cytokines (A) interleukin-6 (IL-6), (B) interferon-gamma (IFN-γ), and (C) tissue necrosis factor-alpha (TNF-α) did not change significantly as a result of multiple MSC injections. Neither (D) IL-17 nor (E) transforming growth factor-beta (TGF-β) was modulated by MSC administration. These data demonstrate that multiple high-dose injections of allogeneic MSCs do not result in a systemic inflammatory response. Data are presented as mean ± standard error of the mean. Grey boxes demonstrate the 95% confidence interval (CI) of the day 0 and control samples. AT, adipose tissue; BM, bone marrow; D, day.

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