Figure 4
From: Hematopoiesis: from start to immune reconstitution potential
Hematopoietic stem cell maintenance. Purified long-term hematopoietic stem cells (HSCs) from adult animals can reconstitute immune-deficient hosts in vivo. However, hematopoietic cells generated in vitro cannot achieve the same functional outcome. The self-renewal capacity can be induced with the expression of homeobox B4 (HoxB4) ectopically in developing embryonic stem cells, indicating that this potential is present although the trigger is unknown.