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Table 1 Recipient horse and donor MSC information

From: Equine allogeneic bone marrow-derived mesenchymal stromal cells elicit antibody responses in vivo

Recipient information

Donor (ELA-A2) information

Horse a

Breed

Age (years)

Sex

Horse a

MSC passage

MSC MHC class II status

Number of MSCs injected

A

Grade

20

Gelding

4 (1)

P4

Negative

46 × 106

B

Thoroughbred

15

Gelding

9

P5

Negative

50 × 106

C

Holsteiner

13

Gelding

ND

P5

Negative

50 × 106

D

Standardbred

16

Gelding

9

P3

Positive

50 × 106

E

Thoroughbred

15

Mare

6

P5

Positive

33 × 106

F

Thoroughbred

18

Gelding

4 (2)

P5

Positive

50 × 106

Control (Horse 2)

Thoroughbred

14

Gelding

9

P5

Negative

50 × 106

  1. ELA-A2, equine leukocyte antigen haplotype; MHC, major histocompatibility complex; MSC, mesenchymal stromal/stem cell; ND, not described. aAll MHC-mismatched MSC recipients were identified by letter. All MHC homozygote horses were identified by number including the ELA-A2 homozygote that was the MHC-matched MSC control recipient. MSCs from all donor ELA-A2 homozygotes were immunophenotyped as described previously [24], except for the one donor listed as Horse ND who was not included in the previous study. Horse ND’s MSCs were positive for MHC class I and had an expected MSC marker panel consistent with the other previously described MSCs.