Proangiogenic progenitor cells (PACs), defined as CD45−KDR+Sca-1+ cells, analyzed on day 28 in peripheral blood and bone marrow of db/db mice injected with conditioned media from C2C12-Luc-GFP, C2C12-Luc-GFP-HO1 cells or nonconditioned control media. (A) Percentage of PACs in bone marrow. (B) Percentage of PACs in peripheral blood. (C) Number of PACs in peripheral blood. Fluorescence-activated cell sorting analysis. Each bar represents mean + SEM (n = 5 to 6). *P < 0.05, versus control, #
P < 0.05, versus C2C12-Luc-GFP. WBC, white blood cell.