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Table 2 Proteins which concentrations differ significantly when harvested from C2C12-Luc-GFP and C2C12-Luc-GFP-HO1 cells

From: Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice

 

Protein

Fold of change HO-1:GFP

Properties of protein

Selected references

Angiogenesis

Myogenic

Pro

Anti

Pro

Anti

Downregulated in C2C12-Luc-GFP-HO1 cells

PEDF

only in GFP

 

+

  

[57,62]

BGN

only in GFP

 

+

+

 

[67-69]

FRP1

only in GFP

+

 

+

 

[66,70]

Fibronectin

0.2

+

 

+

 

[65,71]

Upregulated in C2C12-Luc-GFP-HO1 cells

PDI

only in HO-1

+

   

[72]

PPIase A

2.59

+

  

+

[58,73]

MIF

3.06

+

  

+

[59,63]

Haptoglobin

1.72

+

   

[60]

Galectin-1

1.86

+

 

+

 

[61,64,74]

  1. Mass spectroscopy analysis. Major activities related to angiogenesis and myogenesis are indicated, based on selected references. BGN, biglycan; FRP1, follistatin-related protein 1; GFP, green fluorescent protein; HO-1, heme oxygenase-1; MIF, macrophage migration inhibitory factor; PDI, protein disulfide isomerase; PEDF, pigment epithelium derived factor; PPIase A, peptidyl-prolyl cis-trans isomerase A.