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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6

Figure 5

Effects of implantation of DFAT cells on mRNA expression of renal injury markers and nephrin in renal cortex in mAb 1-22-3-injected rats. Wistar rats were nephrectomized and injected without mAb 1-22-3 (Control) or with 0.5 mg mAb 1-22-3 through the tail vein seven days after the nephrectomy. Thirty five days after the nephrectomy saline (Saline) or 106 DFAT cells were injected through the renal artery (DFAT ia) or tail vein (DFAT iv). Sixty-three days after the nephrectomy, the left kidney was removed. Real-time quantitative PCR was performed to determine the expression of Kim-1 (A), collagen IV (B), fibronectin (C) and nephrin (D) mRNAs. Data are the mean ± SEM (n = 6). *P <0.05 and **P <0.01 in the indicated columns. DFAT, dedifferentiated fat; Kim-1, kidney injury molecule; mAb, monoclonal antibody; SEM, standard error of the mean.

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