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Figure 8 | Stem Cell Research & Therapy

Figure 8

From: Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6

Figure 8

Effects of implantation of DFAT cells on leukocyte accumulation in glomeruli in mAb 1-22-3-injected rats. Wistar rats were nephrectomized and injected without mAb 1-22-3 (Control) or with 0.5 mg mAb 1-22-3 through the tail vein seven days after nephrectomy. Thirty-five days after nephrectomy, saline (Saline) or 106 DFAT cells were injected through the renal artery (DFAT ia) or tail vein (DFAT iv). Sixty-three days after nephrectomy, the left kidney was removed. Immunohistochemical analysis was performed. Numbers of ED1 cells (A: monocytes/macrophages), OX1+ cells (B: common leukocytes), OX19+ cells (C: pan T cells) and OX38+ cells (D: CD4 T lymphocytes) per glomerular cross-section were counted in 50 randomly selected full-sized glomeruli. Data are the mean ± SEM (n = 6). *P <0.05 and **P <0.01 in the indicated columns. Bar = 50 μm. DFAT, dedifferentiated fat; mAb, monoclonal antibody; SEM, standard error of the mean.

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