Figure 6From: Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion modelhADSC tracing by histoimmunostaining with GFAP antibody. MCAO mouse group with PBS injection instead of hADSC serving as the negative control (MCAO-Ctrl-PBS) (A), normal mice with blood vessel exposure only but not occlusion (MCAO-Sham) (B), MCAO mouse group with hADSC injection seven days after MCAO surgery (MCAO-hADSC) (C). Quantitative analysis of GFP labeled hADSCs, GFAP+ relative to the DAPI+ means astrocytes cells take the ratio of total cells in both the Ipsilateral and Contralateral of different groups of the MCAO brain, GFP relative to the DAPI+ means the survival hADSCs take the ratio of total brain cells, GFP + /GFAP + relative to DAPI + means the hADSCs transdifferentiated into astrocytes take the ratio of total brain cells (D). *, ** and *** indicates that significant differences were found between groups (P<0.05, P<0.01 and P<0.001, respectively). DAPI, 4',6-diamidino-2-phenylindole; GFAP, glial fibrillary acidic protein; hADSC, human adipose-derived stem cells; MCAO, middle cerebral artery occlusion.Back to article page