Figure 7

UCX® three-dimensional culture-derived conditioned medium (CM3D) enhanced wound healing in vivo. (A) Graph represents the day of closure of wounds treated with two-dimensional conditioned medium (CM2D), CM3D and control. Data are shown as mean ± standard error of the mean (SEM); n = 6. (B) Representative images (left) of macroscopic view and (right) histological slices stained by haematoxylin and eosin of CM2D-treated, CM3D-treated, control and sham-treated wounds at day 14; n = 6. (C) Graphs represent the histological scores (top to bottom) of wound margin distance, re-epithelialization, granulation tissue and vascularization, evaluated in CM2D-, CM3D-, control and sham-treated wounds at days 7 (n = 4), 9 (n = 5) and 14 (n = 6). Data are shown as mean ± SEM. *P < 0.05; **P < 0.01. GT, granulation tissue; Ep, epithelium; HF, hair follicle; Gl, gland.