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Table 2 Details on mesenchymal stromal cells used in clinical studies

From: Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review

Cell type

Cell carrier

Cell dose

Expansion medium

Passage

Characterization

Reference

BMMSC

Collagen gel

5ā€‰Ć—ā€‰106/ml

Ī±MEM, 15% AS

Single passaged

CD73, CD90, CD105+, CD14, CD34, HLA-DR-

[25,27,28]

BMMSC

Hydroxyapatite ceramic

1.15ā€‰Ć—ā€‰106 in total

DMEM, 15% AS

Single passaged

Ā 

[26]

BMMSC

Fibrin glue with periosteum

2ā€‰Ć—ā€‰106 cells/cm2

DMEM, 10% FBS, 50Ā Ī¼g/ml AA2P, 1% antibiotic-antimycotic

Single passaged

CD90, CD105+, CD14, CD34-

[38]

BMMSC

Platelet-rich fibrin gel

2ā€‰Ć—ā€‰106 cells/cm2

DMEM, 10% FBS, 1% pen/strep

Single passaged

CD73+, CD34, CD45-

[29]

BMMSC

Collagen scaffold

Ā 

DMEM, 10%, FBS 1% pen/strep

Passaged

Ā 

[30]

BMMSC

Membrane

Ā Ā Ā Ā 

NCT00885729

BMMSC

Periosteum

Ā Ā 

Passaged

Ā 

NCT00891501

BMMSC

Type I collagen scaffold

Ā Ā 

Passaged

Ā 

NCT00850187

PBMSC

Collagen membrane

1.25-5.2ā€‰Ć—ā€‰106

N/A

Unpassaged

Ā 

[40]

ATMSC

Periosteum

Ā Ā 

Passaged

Ā 

NCT01399749

SMSC

SMSC TEC

Ā Ā Ā Ā 

[16,17]

UMSC

Sodium hyaluronate

Ā Ā 

Passaged

Ā 

[20] NCT01041001

BMMSC and AC

Fibrin glue

2ā€‰Ć—ā€‰106 cells/cm2

Ī±MEM, 5% platelet lysate

Passage 3

CD73, CD90, CD105+, CD45, CD34, CD11b, CD14, CD31, CD79, CD19, HLA-DR-

[3,46] NCT02037204

  1. Ī±MEM alpha minimal essential medium, AA2P L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, AC autologous chondrons, AS autologous serum, ATMSC adipose tissue-derived mesenchymal stromal cell, BMMSC bone marrow-derived mesenchymal stromal cell, DMEM Dulbeccoā€™s modified Eagle medium, FBS fetal bovine serum, N/A not applicable, PBMSC peripheral blood-derived mesenchymal stromal cell, Pen/strep penicillin/streptomycin, SMSC synovium-derived mesenchymal stromal cell, TEC tissue engineered construct, UMSC umbilical cord blood-derived mesenchymal stromal cell